Jump to main content
Jump to site search

Issue 40, 2014
Previous Article Next Article

Catalytic intermolecular β-C–H alkenylation of α-enamino-ketones with simple alkynes

Author affiliations

Abstract

A unique strategy to synthesize β-alkenylated α-enamino-ketones via catalytic C–H/alkyne coupling is described. The slow addition of alkyne substrates and the use of NaI as an additive play key roles in controlling the alkyne insertion. Replacement of the pyridyl group with carbamates was also developed. This method allows for rapid synthesis of highly functionalized vinyl-substituted enamino-ketones.

Graphical abstract: Catalytic intermolecular β-C–H alkenylation of α-enamino-ketones with simple alkynes

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 02 Oct 2013, accepted on 04 Nov 2013, published on 05 Nov 2013 and first published online on 05 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC47556E
Citation: Chem. Commun., 2014,50, 5230-5232
  •   Request permissions

    Catalytic intermolecular β-C–H alkenylation of α-enamino-ketones with simple alkynes

    Z. Wang, B. J. Reinus and G. Dong, Chem. Commun., 2014, 50, 5230
    DOI: 10.1039/C3CC47556E

Search articles by author