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Issue 40, 2014
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Tracking chemical reactions on the surface of filamentous phage using mass spectrometry

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Abstract

Chemical modification of phage libraries has allowed the in vitro evolution of ligands having properties not provided by natural polypeptides. The development of novel and more diverse chemical reactions on phage was hampered by the lack of analytical methods to efficiently monitor the reaction products on the more than 10 000 kDa large filamentous phage particles. Herein, we present a strategy to detect chemically modified peptides on phage based on enzymatic release of peptide from phage and mass spectrometry analysis.

Graphical abstract: Tracking chemical reactions on the surface of filamentous phage using mass spectrometry

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Publication details

The article was received on 30 Sep 2013, accepted on 14 Nov 2013 and first published on 14 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC47496H
Citation: Chem. Commun., 2014,50, 5267-5269
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    Tracking chemical reactions on the surface of filamentous phage using mass spectrometry

    S. Chen, J. Touati and C. Heinis, Chem. Commun., 2014, 50, 5267
    DOI: 10.1039/C3CC47496H

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