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Issue 13, 2014
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Stereocontrolled generation of nucleophilic (Z)- or (E)-α-fluoroalkenylchromium reagents via carbon–fluorine bond activation: highly stereoselective synthesis of (E)- or (Z)-β-fluoroallylic alcohols

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Abstract

Highly nucleophilic (Z)- or (E)-α-fluoroalkenylchromium species could be generated in a stereoselective manner via C–F bond activation of CBrF2-containing molecules, and they reacted smoothly with various aldehydes to give (E)- or (Z)-β-fluoroallylic alcohol derivatives in high yields, respectively.

Graphical abstract: Stereocontrolled generation of nucleophilic (Z)- or (E)-α-fluoroalkenylchromium reagents via carbon–fluorine bond activation: highly stereoselective synthesis of (E)- or (Z)-β-fluoroallylic alcohols

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Publication details

The article was received on 21 Sep 2013, accepted on 30 Nov 2013 and first published on 02 Jan 2014


Article type: Communication
DOI: 10.1039/C3CC47219A
Citation: Chem. Commun., 2014,50, 1543-1545
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    Stereocontrolled generation of nucleophilic (Z)- or (E)-α-fluoroalkenylchromium reagents via carbon–fluorine bond activation: highly stereoselective synthesis of (E)- or (Z)-β-fluoroallylic alcohols

    T. Nihei, S. Yokotani, T. Ishihara and T. Konno, Chem. Commun., 2014, 50, 1543
    DOI: 10.1039/C3CC47219A

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