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Issue 2, 2014
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Hydration, ionic valence and cross-linking propensities of cations determine the stability of lipopolysaccharide (LPS) membranes

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Abstract

The supra-molecular structure of LPS aggregates governs outer membrane permeability and activation of the host immune response during Gram-negative bacterial infections. Molecular dynamics simulations unveil at atomic resolution the subtle balance between cation hydration and cross-linking ability in modulating phase transitions of LPS membranes.

Graphical abstract: Hydration, ionic valence and cross-linking propensities of cations determine the stability of lipopolysaccharide (LPS) membranes

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Publication details

The article was received on 10 Sep 2013, accepted on 24 Oct 2013 and first published on 29 Oct 2013


Article type: Communication
DOI: 10.1039/C3CC46918B
Citation: Chem. Commun., 2014,50, 231-233
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    Hydration, ionic valence and cross-linking propensities of cations determine the stability of lipopolysaccharide (LPS) membranes

    A. Nascimento, F. J. S. Pontes, R. D. Lins and T. A. Soares, Chem. Commun., 2014, 50, 231
    DOI: 10.1039/C3CC46918B

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