Jump to main content
Jump to site search

Issue 2, 2014
Previous Article Next Article

Conversion of nitrite to nitric oxide at zinc via S-nitrosothiols

Author affiliations

Abstract

Nitrite is an important reservoir of nitric oxide activity in the plasma and cells. Using a biomimetic model, we demonstrate the conversion of zinc-bound nitrite in the tris(pyrazolyl)borate complex iPr2TpZn(NO2) to the corresponding S-nitrosothiol RSNO and zinc thiolate iPr2TpZn–SR via reaction with thiols H–SR. Decomposition of the S-nitrosothiol formed releases nitric oxide gas.

Graphical abstract: Conversion of nitrite to nitric oxide at zinc via S-nitrosothiols

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Aug 2013, accepted on 27 Oct 2013 and first published on 28 Oct 2013


Article type: Communication
DOI: 10.1039/C3CC46102E
Citation: Chem. Commun., 2014,50, 168-170
  •   Request permissions

    Conversion of nitrite to nitric oxide at zinc via S-nitrosothiols

    A. J. P. Cardenas, R. Abelman and T. H. Warren, Chem. Commun., 2014, 50, 168
    DOI: 10.1039/C3CC46102E

Search articles by author

Spotlight

Advertisements