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Issue 23, 2014
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Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor

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Abstract

The RNA motifs that bind guanidinylated kanamycin A (G Kan A) and guanidinylated neomycin B (G Neo B) were identified via two-dimensional combinatorial screening (2DCS). The results of these studies enabled the “bottom-up” design of a small molecule inhibitor of oncogenic microRNA-10b.

Graphical abstract: Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor

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Publication details

The article was received on 08 Jan 2013, accepted on 19 Dec 2013 and first published on 17 Jan 2014


Article type: Communication
DOI: 10.1039/C3CC00173C
Citation: Chem. Commun., 2014,50, 3027-3029
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    Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor

    S. P. Velagapudi and M. D. Disney, Chem. Commun., 2014, 50, 3027
    DOI: 10.1039/C3CC00173C

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