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Issue 2, 2014
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Programmable polymer-DNA hydrogels with dual input and multiscale responses

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Abstract

Combination switchable polymer-DNA hydrogels have been synthesized to respond to both a specific oligonucleotide recognition signal and a non-specific but biorelevant environmental trigger. The hydrogels exhibit rheological properties that can be modulated through interaction with complementary DNA strands and/or reduction. Furthermore, individual and combined oligonucleotide recognition and reduction responses allow control over pore sizes in the gel, enabling programmable release and transport of objects ranging from the nano- to micro-scale.

Graphical abstract: Programmable polymer-DNA hydrogels with dual input and multiscale responses

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Publication details

The article was received on 13 May 2013, accepted on 28 Aug 2013 and first published on 04 Oct 2013


Article type: Paper
DOI: 10.1039/C3BM60126A
Citation: Biomater. Sci., 2014,2, 203-211
  • Open access: Creative Commons BY license
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    Programmable polymer-DNA hydrogels with dual input and multiscale responses

    G. Sicilia, C. Grainger-Boultby, N. Francini, J. P. Magnusson, A. O. Saeed, F. Fernández-Trillo, S. G. Spain and C. Alexander, Biomater. Sci., 2014, 2, 203
    DOI: 10.1039/C3BM60126A

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