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Issue 14, 2014
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Nanoscale-controlled architecture for the development of ultrasensitive lectin biosensors applicable in glycomics

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Abstract

In this mini-review the most advanced patterning protocols and transducing schemes for the development of ultrasensitive label-free and label-based lectin biosensors for the glycoprofiling of disease markers and some cancerous cells are described. The performance of such lectin biosensors with interfacial properties tuned to the nanoscale are critically compared to the most sensitive immunoassay format of analysis, and challenges for the future are discussed. In addition the key elements for further development of these devices are considered, with a view to improvement of their robustness and practical applicability.

Graphical abstract: Nanoscale-controlled architecture for the development of ultrasensitive lectin biosensors applicable in glycomics

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Publication details

The article was received on 27 Feb 2014, accepted on 16 May 2014 and first published on 11 Jun 2014


Article type: Minireview
DOI: 10.1039/C4AY00495G
Citation: Anal. Methods, 2014,6, 4922-4931
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    Nanoscale-controlled architecture for the development of ultrasensitive lectin biosensors applicable in glycomics

    L. Kluková, T. Bertok, P. Kasák and J. Tkac, Anal. Methods, 2014, 6, 4922
    DOI: 10.1039/C4AY00495G

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