Jump to main content
Jump to site search

Issue 13, 2014
Previous Article Next Article

Degradation study of nitroaromatic explosives 2-diazo-4,6-dinitrophenol and picramic acid using HPLC and UHPLC-ESI-MS/MS

Author affiliations

Abstract

A new and fast HPLC method with UV detection was developed and validated for the simultaneous determination of nitroaromatic explosives diazodinitrophenol (DDNP), the raw material picramic acid (PicA) and three degradation products of DDNP. DDNP and PicA were subjected to forced degradation. DDNP was found to be stable under acidic and basic conditions, while thermal, oxidative and photolytic decomposition resulted in three degradation products. Degradation products were separated from DDNP using Ascentis® Express C18 fused core particle column and subsequently characterised using UHPLC-ESI-MS/MS method. Optimal chromatography was performed using the isocratic elution of mobile phase consisting of acetonitrile–orthophosphoric acid 0.085% 30 : 70 (v/v) pumped at a flow rate of 0.8 mL min−1 at a temperature of 50 °C. System suitability test parameters, linearity and precision of the HPLC method were evaluated. The new HPLC method is suitable for a fast determination of DDNP and degradation products in various samples. Our work provides a basic view on the stability and aspects of degradation process of nitroaromatics DDNP and PicA, and shows the formation of degradation products.

Graphical abstract: Degradation study of nitroaromatic explosives 2-diazo-4,6-dinitrophenol and picramic acid using HPLC and UHPLC-ESI-MS/MS

Back to tab navigation

Publication details

The article was received on 18 Feb 2014, accepted on 02 May 2014 and first published on 02 May 2014


Article type: Paper
DOI: 10.1039/C4AY00401A
Citation: Anal. Methods, 2014,6, 4761-4768
  •   Request permissions

    Degradation study of nitroaromatic explosives 2-diazo-4,6-dinitrophenol and picramic acid using HPLC and UHPLC-ESI-MS/MS

    L. Havlíková, R. Matyáš, L. Ihnát, L. Nováková and D. Šatínský, Anal. Methods, 2014, 6, 4761
    DOI: 10.1039/C4AY00401A

Search articles by author

Spotlight

Advertisements