Issue 15, 2014
From the journal:

Analyst

Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein†

Brandon W. Heimer,a   Tatyana A. Shatova,a   Jungkyu K. Lee,b   Kaja Kaastrupa  and  Hadley D. Sikes*a  

* Corresponding authors

a Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02129, USA
E-mail: sikes@mit.edu

b Department of Chemistry, Kyungpook National University, Daegu, South Korea

Abstract

Hypermethylation of CpG islands in gene promoter regions has been shown to be a predictive biomarker for certain diseases. Most current methods for methylation profiling are not well-suited for clinical analysis. Here, we report the development of an inexpensive device and an epigenotyping assay with a format conducive to multiplexed analysis.

Graphical abstract: Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein

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Article information

DOI
https://doi.org/10.1039/C4AN00667D
Article type
Communication
Submitted
14 Apr 2014
Accepted
28 Apr 2014
First published
28 Apr 2014
This article is Open Access
Creative Commons BY-NC license

Analyst, 2014,139, 3695-3701

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Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein

B. W. Heimer, T. A. Shatova, J. K. Lee, K. Kaastrup and H. D. Sikes, Analyst, 2014, 139, 3695 DOI: 10.1039/C4AN00667D

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