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Issue 9, 2014
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DNA-embedded Au–Ag core–shell nanoparticles assembled on silicon slides as a reliable SERS substrate

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Abstract

This study aimed at developing a sensitive and reliable SERS substrate by assembling DNA-embedded Au–Ag core–shell nanoparticles (NPs) on silicon slides. First, a monolayer of well separated DNA-functionalized Au NPs (40 nm) was decorated on (3-aminopropyl)triethoxysilane modified silicon slides. The DNA-embedded Au–Ag core–shell NPs were assembled on the 40 nm Au–DNA NPs to form a core–satellite structure through DNA hybridization. Using 4-MBA as a Raman dye, the SERS performance of the substrates was evaluated after being cleaned by low oxygen and argon plasma. The Raman intensity of the assembly using DNA-embedded Au–Ag core–shell NPs was 8–10 times higher than the intensity of the assembly using Au NPs as satellites. In addition, the signal-to-noise ratio of the assembly was 2.6 times higher than that of a commercial substrate (Klarite™) when a 785 nm laser was used. The SERS enhancements of the assembled substrates were 2.2 to 2.8 times higher than the Klarite when an acquisition time of 5 s was used at an excitation wavelength of 633 nm. The assembled substrates also show a good spot-to-spot and substrate-to-substrate reproducibility at the excitation wavelengths of 633 and 785 nm. These results demonstrate that the fabrication process is simple and cost-effective for assembling DNA-embedded Au–Ag core–shell NPs on silicon slides that can be used as a reliable SERS substrate.

Graphical abstract: DNA-embedded Au–Ag core–shell nanoparticles assembled on silicon slides as a reliable SERS substrate

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Publication details

The article was received on 13 Nov 2013, accepted on 09 Feb 2014 and first published on 13 Mar 2014


Article type: Paper
DOI: 10.1039/C3AN02116E
Citation: Analyst, 2014,139, 2207-2213
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    DNA-embedded Au–Ag core–shell nanoparticles assembled on silicon slides as a reliable SERS substrate

    Z. Zhang, S. Zhang and M. Lin, Analyst, 2014, 139, 2207
    DOI: 10.1039/C3AN02116E

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