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Issue 23, 2014
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Label-free detection of DNA by combining gated mesoporous silica and catalytic signal amplification of platinum nanoparticles

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Abstract

This article presents a simple label-free detection of nucleic acids by using Pt@mesoporousSiO2 as a “smart” reporter, whose pores are first capped by single-stranded (ss) probe DNA. The detection signal is then amplified using the TMB oxidation reaction catalysed by Pt NPs while hybridizing with the complementary ss target DNA, which makes the pores of mesoporous SiO2 open through hybridization.

Graphical abstract: Label-free detection of DNA by combining gated mesoporous silica and catalytic signal amplification of platinum nanoparticles

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Publication details

The article was received on 22 Aug 2014, accepted on 30 Sep 2014 and first published on 30 Sep 2014


Article type: Communication
DOI: 10.1039/C4AN01539H
Citation: Analyst, 2014,139, 6088-6091
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    Label-free detection of DNA by combining gated mesoporous silica and catalytic signal amplification of platinum nanoparticles

    Z. Wang, X. Yang, J. Feng, Y. Tang, Y. Jiang and N. He, Analyst, 2014, 139, 6088
    DOI: 10.1039/C4AN01539H

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