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Issue 21, 2014
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Sensing with nanopores – the influence of asymmetric blocking on electrochemical redox cycling current

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Abstract

Nanoporous redox cycling devices are highly efficient tools for the electrochemical sensing of redox-active molecules. By using a redox-active mediator, this concept can be exploited for the detection of molecular binding events via blocking of the redox cycling current within the nanopores. Here, we investigate the influence of different blocking scenarios inside a nanopore on the resulting redox cycling current. Our analysis is based on random walk simulations and finite element calculations. We distinguish between symmetric and asymmetric pore blocking and show that the current decrease is more pronounced in the case of asymmetric blocking reflecting the diffusion-driven pathway of the redox-active molecules. Using random walk simulations, we further study the impact of pore blocking in the frequency domain and identify relevant features of the power spectral density, which are of particular interest for sensing applications based on fluctuation analysis.

Graphical abstract: Sensing with nanopores – the influence of asymmetric blocking on electrochemical redox cycling current

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Publication details

The article was received on 30 Jul 2014, accepted on 03 Sep 2014 and first published on 03 Sep 2014


Article type: Paper
DOI: 10.1039/C4AN01401D
Citation: Analyst, 2014,139, 5499-5503
  • Open access: Creative Commons BY license
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    Sensing with nanopores – the influence of asymmetric blocking on electrochemical redox cycling current

    K. J. Krause, E. Kätelhön, S. G. Lemay, R. G. Compton and B. Wolfrum, Analyst, 2014, 139, 5499
    DOI: 10.1039/C4AN01401D

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