Jump to main content
Jump to site search

Issue 15, 2014
Previous Article Next Article

Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein

Author affiliations

Abstract

Hypermethylation of CpG islands in gene promoter regions has been shown to be a predictive biomarker for certain diseases. Most current methods for methylation profiling are not well-suited for clinical analysis. Here, we report the development of an inexpensive device and an epigenotyping assay with a format conducive to multiplexed analysis.

Graphical abstract: Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein

Back to tab navigation

Supplementary files

Publication details

The article was received on 14 Apr 2014, accepted on 28 Apr 2014 and first published on 28 Apr 2014


Article type: Communication
DOI: 10.1039/C4AN00667D
Citation: Analyst, 2014,139, 3695-3701
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein

    B. W. Heimer, T. A. Shatova, J. K. Lee, K. Kaastrup and H. D. Sikes, Analyst, 2014, 139, 3695
    DOI: 10.1039/C4AN00667D

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements