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Issue 5, 2014
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A mesofluidic platform integrating on-chip probe ultrasonication for multiple sample pretreatment involving denaturation, reduction, and digestion in protein identification assays by mass spectrometry

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Abstract

The integration of ultrasound (US)-assisted sample processing on-chip in a lab-on-a-valve (LOV) format for automated high-throughput shotgun proteomic assays is herein presented for the first time. The proof of concept of this system was demonstrated with the analysis of three proteins and sera from patients with lymphoma or myeloma.

Graphical abstract: A mesofluidic platform integrating on-chip probe ultrasonication for multiple sample pretreatment involving denaturation, reduction, and digestion in protein identification assays by mass spectrometry

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Publication details

The article was received on 23 Nov 2013, accepted on 03 Jan 2014 and first published on 20 Jan 2014


Article type: Communication
DOI: 10.1039/C3AN02178E
Author version available: Download Author version (PDF)
Citation: Analyst, 2014,139, 992-995
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    A mesofluidic platform integrating on-chip probe ultrasonication for multiple sample pretreatment involving denaturation, reduction, and digestion in protein identification assays by mass spectrometry

    J. D. Nunes-Miranda, C. Núñez, H. M. Santos, G. Vale, M. Reboiro-Jato, F. Fdez-Riverola, C. Lodeiro, M. Miró and J. L. Capelo, Analyst, 2014, 139, 992
    DOI: 10.1039/C3AN02178E

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