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Issue 96, 2013
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Negishi coupling reactions as a valuable tool for [11C]methyl-arene formation; first proof of principle

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Abstract

The Negishi coupling reaction between arylzinc halide reagents and 11CH3I has been used to synthesise 11C-methylated arene species via a palladium-mediated process. The metabotropic glutamate receptor subtype-5 radiotracer [11C]MPEP has been radiolabelled using this technique.

Graphical abstract: Negishi coupling reactions as a valuable tool for [11C]methyl-arene formation; first proof of principle

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Publication details

The article was received on 20 Sep 2013, accepted on 17 Oct 2013 and first published on 18 Oct 2013


Article type: Communication
DOI: 10.1039/C3CC47203E
Citation: Chem. Commun., 2013,49, 11326-11328
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    Negishi coupling reactions as a valuable tool for [11C]methyl-arene formation; first proof of principle

    S. Kealey, J. Passchier and M. Huiban, Chem. Commun., 2013, 49, 11326
    DOI: 10.1039/C3CC47203E

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