Negishi coupling reactions as a valuable tool for [11C]methyl-arene formation; first proof of principle†
Abstract
The Negishi coupling reaction between arylzinc halide reagents and 11CH3I has been used to synthesise 11C-methylated arene species via a palladium-mediated process. The metabotropic glutamate receptor subtype-5 radiotracer [11C]MPEP has been radiolabelled using this technique.