Jump to main content
Jump to site search

Issue 46, 2013
Previous Article Next Article

Metal chelating crosslinkers form nanogels with high chelation stability

Author affiliations

Abstract

We present a series of hydrogel nanoparticles (nanogels) incorporating either acyclic or cyclic gadolinium chelates as crosslinkers. These crosslinkers are used to formulate polyacrylamide-based nanogels (diameter 50 to 85 nm) yielding contrast agents with enhanced relaxivities (up to 6-fold greater than Dotarem®), because the nanogel structure slows the chelator's tumbling frequency and allows fast water exchange. Importantly, these nanogels also stabilize Gd3+ within the chelator thermodynamically and kinetically against metal displacement through transmetallation, which should reduce toxicity associated with release of free Gd3+. This chelation stability suggests that the chelate crosslinker strategy may prove useful for other applications of metal-chelating nanoparticles in medicine, including other imaging modalities and radiotherapy.

Graphical abstract: Metal chelating crosslinkers form nanogels with high chelation stability

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Aug 2013, accepted on 26 Sep 2013 and first published on 27 Sep 2013


Article type: Paper
DOI: 10.1039/C3TB21104E
Citation: J. Mater. Chem. B, 2013,1, 6359-6364
  •   Request permissions

    Metal chelating crosslinkers form nanogels with high chelation stability

    J. Lux, M. Chan, L. Vander Elst, E. Schopf, E. Mahmoud, S. Laurent and A. Almutairi, J. Mater. Chem. B, 2013, 1, 6359
    DOI: 10.1039/C3TB21104E

Search articles by author

Spotlight

Advertisements