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Issue 42, 2013
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Dye-enhanced graphene oxide for photothermal therapy and photoacoustic imaging

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Abstract

Graphene oxide (GO) has many exciting advantages such as easy preparation, low toxicity, good solubility and stability in aqueous solution. However, GO itself has a low near-infrared (NIR) absorption, and thus is not suitable for photothermal therapy and photoacoustic imaging. To overcome this limitation, a novel dye-enhanced GO is prepared utilizing the π–π stacking interactions between GO and indocyanine green (ICG). The ICG–GO complex has a high optical absorbance in the NIR region and exhibits excellent photothermal properties under NIR irradiation. In order to improve the cancer-targeting activity, GO was modified with folic acid (FA). In vitro experiments showed that the ICG–GO–FA nanocomposite could be used for targeted photothermal cancer cell destruction. Moreover, the application of the ICG–GO–FA nanocomposite for photoacoustic imaging was also demonstrated.

Graphical abstract: Dye-enhanced graphene oxide for photothermal therapy and photoacoustic imaging

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Publication details

The article was received on 17 Jul 2013, accepted on 09 Sep 2013 and first published on 10 Sep 2013


Article type: Paper
DOI: 10.1039/C3TB20986E
Citation: J. Mater. Chem. B, 2013,1, 5762-5767
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    Dye-enhanced graphene oxide for photothermal therapy and photoacoustic imaging

    Y. Wang, Y. Fu, Q. Peng, S. Guo, G. Liu, J. Li, H. Yang and G. Chen, J. Mater. Chem. B, 2013, 1, 5762
    DOI: 10.1039/C3TB20986E

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