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Issue 38, 2013
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Blood compatibility of a new zwitterionic bare metal stent with hyperbranched polymer brushes

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Abstract

Different approaches have been used in developing new coronary stents to protect against thrombosis and minimize restenosis. Here we describe a new zwitterionic bare metal stent (BMS) surface based on 2-((bromobutyryl)oxy)ethyl acrylate (BBEA) hyperbranched polymer. The new BMS produced was studied for its blood compatibility. The hemocompatibility studied including platelet adhesion tests, hemolysis assay, morphological changes of red blood cells (RBCs), coagulation time tests, plasma recalcification time (PRT) assay, complement activation, and platelet activation at the molecular level. Moreover the cytotoxicity of BMS before and after modification was also characterized by MTT assays. Most assays had remarkable differences in the presence of the new zwitterionic BMS, indicating the importance of the zwitterion.

Graphical abstract: Blood compatibility of a new zwitterionic bare metal stent with hyperbranched polymer brushes

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Publication details

The article was received on 15 Jun 2013, accepted on 30 Jul 2013 and first published on 31 Jul 2013


Article type: Paper
DOI: 10.1039/C3TB20855A
Citation: J. Mater. Chem. B, 2013,1, 5036-5044
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    Blood compatibility of a new zwitterionic bare metal stent with hyperbranched polymer brushes

    X. Wang, X. Chen, L. Xing, C. Mao, H. Yu and J. Shen, J. Mater. Chem. B, 2013, 1, 5036
    DOI: 10.1039/C3TB20855A

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