Jump to main content
Jump to site search

Issue 46, 2013
Previous Article Next Article

Preparation and characterization of a novel hybrid hydrogel shell for localized photodynamic therapy

Author affiliations

Abstract

Due to the limits of photodynamic therapy (PDT) in clinical use, the development of a new system for PDT may hold promise to improve the situation. In this article, we report the preparation of a novel hybrid hydrogel (HHG) containing poly (ethylene glycol) double acrylates (PEGDA), polyethylene glycol 400 (PEG400), phthalocyanine zinc (ZnPc) and phosphotungstic acid (PTA) based on in situ photopolymerization. ZnPc is used as both the photoinitiator for initiating the formation of HHG and the photosensitizer for producing singlet oxygen to kill tumor cells. PTA plays a significant co-initiator role in the photopolymerization process and has a positive impact on the acceleration of singlet oxygen generation. The HHG shows good biocompatibility, swelling and drug retention abilities, and especially can be easily and rapidly formed on tumor cells in situ by irradiating the precursor with near-infrared light. The HHG shell not only prevents diffusion of the photosensitizer, but also maintains a high ZnPc concentration in or on tumor cells for more effective PDT. Thus, this novel HHG is an attractive candidate for local PDT and has a huge potential application in the future development of cancer treatment.

Graphical abstract: Preparation and characterization of a novel hybrid hydrogel shell for localized photodynamic therapy

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 03 Jun 2013, accepted on 18 Sep 2013 and first published on 18 Sep 2013


Article type: Paper
DOI: 10.1039/C3TB20779J
Citation: J. Mater. Chem. B, 2013,1, 6411-6417
  •   Request permissions

    Preparation and characterization of a novel hybrid hydrogel shell for localized photodynamic therapy

    Y. Wang, B. Han, R. Shi, L. Pan, H. Zhang, Y. Shen, C. Li, F. Huang and A. Xie, J. Mater. Chem. B, 2013, 1, 6411
    DOI: 10.1039/C3TB20779J

Search articles by author