Highly selective recognition and ultrasensitive quantification of enantiomers

Liguang Xu; Zhou Xu; Wei Ma; Liqiang Liu; Libing Wang; Hua Kuang; Chuanlai Xu

doi:10.1039/C3TB20692K

Highly selective recognition and ultrasensitive quantification of enantiomers

Liguang Xu,^a Zhou Xu,^a^b Wei Ma,^a Liqiang Liu,^a Libing Wang,^a Hua Kuang*^a and Chuanlai Xu^a

* Corresponding authors

^a State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China
E-mail: khecho@163.com
Tel: +86-510-85329076

^b School of Chemistry and Biology Engineering, Changsha University of Science & Technology, Changsha 410114, China

Abstract

The ability to recognize and quantify the molecular chirality of enantiomers at the nanolevel in biological systems constitutes the basis of many critical areas for specific targeting in drug development and metabolite probing. Plasmonic nanoparticle dimers exhibit circular dichroism effects at visible wavelengths, amplifying the chiral signal of chiral molecules. We demonstrate the self-assembly of plasmonic chiroptical dimers through multibody attractive forces mediated by cysteine, which amplified the plasmonic chirality of enantiomers using enantiomeric cysteines (L and D), and achieved chiral recognition and a quantitative chiroptical sensing platform, with a detection limit of 20 pM level for L-cysteine. The versatility of nanoparticle dimers with customized chiroptical response opens up the avenue for adaptation of the plasmonic chiroptical platform for the drug development and proteomic profiling of metabolites.

Supplementary files

Publication details

The article was received on 18 May 2013, accepted on 10 Jul 2013 and first published on 11 Jul 2013

Article type: Paper

DOI: 10.1039/C3TB20692K

Citation: J. Mater. Chem. B, 2013,1, 4478-4483

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Highly selective recognition and ultrasensitive quantification of enantiomers

L. Xu, Z. Xu, W. Ma, L. Liu, L. Wang, H. Kuang and C. Xu, J. Mater. Chem. B, 2013, 1, 4478
DOI: 10.1039/C3TB20692K
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Journal of Materials Chemistry B

Highly selective recognition and ultrasensitive quantification of enantiomers

Abstract

Supplementary files

Publication details

Highly selective recognition and ultrasensitive quantification of enantiomers

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