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Issue 37, 2013
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Magnetic mesoporous silica nanoparticles end-capped with hydroxyapatite for pH-responsive drug release

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Abstract

Mesoporous silica nanoparticles (MSNs) have emerged as one of the most promising vehicles for potential application in drug delivery. In this paper, we report a novel multifunctional nanocomposite composed of a magnetite nanocrystal core and a mesoporous silica shell (Fe3O4@mSiO2), end-capped with pH-stimuli-responsive hydroxyapatite (HAp) nanovalves for pH-responsive drug release. Iron oxide core and mesoporous silica shell nanoparticles were synthesized using a microemulsion method, and were then employed as templates for surface coating of hydroxyapatite. The efficient coating of the natural nontoxic component hydroxyapatite was achieved through a biomimetic mineralization process. The pH-responsive release of the model drug ibuprofen showed that the Fe3O4@mSiO2@HAp nanoparticles possessed pH-responsive drug-release functionalities. The dissolution of hydroxyapatite in an acidic environment triggers the release of the loaded drugs in Fe3O4@mSiO2@HAp nanoparticles.

Graphical abstract: Magnetic mesoporous silica nanoparticles end-capped with hydroxyapatite for pH-responsive drug release

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Publication details

The article was received on 03 May 2013, accepted on 19 Jul 2013 and first published on 22 Jul 2013


Article type: Paper
DOI: 10.1039/C3TB20641F
Citation: J. Mater. Chem. B, 2013,1, 4828-4833
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    Magnetic mesoporous silica nanoparticles end-capped with hydroxyapatite for pH-responsive drug release

    C. Zhao, L. Yu and A. P. J. Middelberg, J. Mater. Chem. B, 2013, 1, 4828
    DOI: 10.1039/C3TB20641F

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