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Issue 27, 2013
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Antifungal vanillin–imino-chitosan biodynameric films

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Abstract

Vanillinchitosan biodynamers have been prepared and structure–morphology correlations revealed the pathway of progressive incorporation of the aldehyde onto chitosan backbones. Such dynamic biopolymers or biodynamers, generated from reversibly interacting components, offer the possibility to address the dynamic covalent behaviour of the reversible imine-bond formation/hydrolysis equilibria between vanillin and chitosan polymeric backbones. The reaction takes place with very low conversion in acidic aqueous solutions (7–12%), but the imine bond formation is amazingly improved (∼80%) when the reaction takes place while solution–solid state transition and solid state phase-organization events occur. The chitosanvanillin biopolymeric films described here present interesting Candida albicans antifungal activity compared with other common bacterial strands, which suggests the implementation of these biocompatible materials as thin layer protecting systems for medical devices.

Graphical abstract: Antifungal vanillin–imino-chitosan biodynameric films

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Publication details

The article was received on 18 Apr 2013, accepted on 10 May 2013 and first published on 10 May 2013


Article type: Paper
DOI: 10.1039/C3TB20558D
Citation: J. Mater. Chem. B, 2013,1, 3353-3358
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    Antifungal vanillin–imino-chitosan biodynameric films

    L. Marin, I. Stoica, M. Mares, V. Dinu, B. C. Simionescu and M. Barboiu, J. Mater. Chem. B, 2013, 1, 3353
    DOI: 10.1039/C3TB20558D

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