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Issue 25, 2013
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Development of new drug delivery system based on ordered mesoporous carbons: characterisation and cytocompatibility studies

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Abstract

Ordered mesoporous carbons that encapsulate the poorly soluble compounds ibuprofen and indomethacin were systematically studied by means of X-ray diffraction (XRD), differential scanning calorimetry (DSC) and X-ray photon electron spectroscopy (XPS). The results showed marked differences in the release profiles of the two drug molecules in simulated gastric fluids. In vitro toxicity profiles appear to be compatible with potential therapeutic applications bringing them to the forefront as carriers of poorly water soluble drugs.

Graphical abstract: Development of new drug delivery system based on ordered mesoporous carbons: characterisation and cytocompatibility studies

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Publication details

The article was received on 05 Mar 2013, accepted on 29 Apr 2013 and first published on 23 May 2013


Article type: Paper
DOI: 10.1039/C3TB20304B
Citation: J. Mater. Chem. B, 2013,1, 3167-3174
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    Development of new drug delivery system based on ordered mesoporous carbons: characterisation and cytocompatibility studies

    C. Karavasili, E. P. Amanatiadou, L. Sygellou, D. K. Giasafaki, T. A. Steriotis, G. C. Charalambopoulou, I. S. Vizirianakis and D. G. Fatouros, J. Mater. Chem. B, 2013, 1, 3167
    DOI: 10.1039/C3TB20304B

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