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Issue 14, 2013
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Monodisperse magnetites anchored onto carbon nanotubes: a platform for cell imaging, magnetic manipulation and enhanced photothermal treatment of tumors

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Abstract

In this paper, a facile solvothermal synthesis method was developed to prepare monodisperse magnetites anchored onto multi-walled carbon nanotubes (MWNTs). The pristine MWNTs were treated with a mixture of concentrated sulfuric and nitric acids. The oxidized MWNTs (o-MWNTs) had abundant carboxylic groups on the surface, which have a strong ability to chelate metal ions like Fe3+. The obtained MWNTs–Fe3O4 nanomaterials allowed π–π stacking of fluorescein isothiocyanate (FITC) to monitor inside living cancer cells by fluorescence imaging. Cells labeled with MWNTs–Fe3O4 nanomaterials could be efficiently manipulated by a magnetic field due to the large magnetic moment of the iron oxide domain in the nanocomposites. The MWNTs–Fe3O4 nanomaterials have been demonstrated to be effective for in vivo photothermal treatment of tumors using mice implanted with human U87 tumors as a model.

Graphical abstract: Monodisperse magnetites anchored onto carbon nanotubes: a platform for cell imaging, magnetic manipulation and enhanced photothermal treatment of tumors

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Publication details

The article was received on 18 Dec 2012, accepted on 07 Feb 2013 and first published on 28 Feb 2013


Article type: Paper
DOI: 10.1039/C3TB00543G
Citation: J. Mater. Chem. B, 2013,1, 1939-1946
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    Monodisperse magnetites anchored onto carbon nanotubes: a platform for cell imaging, magnetic manipulation and enhanced photothermal treatment of tumors

    S. Shen, J. Ren, X. Zhu, Z. Pang, X. Lu, C. Deng, R. Zhang and X. Jiang, J. Mater. Chem. B, 2013, 1, 1939
    DOI: 10.1039/C3TB00543G

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