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Issue 11, 2013
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Macromolecules on nano-outlets responding to electric field and pH for dual-mode drug delivery

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Abstract

Macromolecules responsive to both electric field and pH are modified on the outlets of mesoporous silica nanospheres to form a novel dual-mode drug delivery system. Dual drug delivery modes are indicated by the release patterns obtained by simulating the body’s gastric and intestinal fluid ex vivo. In a pH 1.4 release medium (simulated gastric fluid, SGF) without an alternating electric field, only 8.5% of the total payload is found to leach in 8 h, whereas 50.3% and 60.2% of the total payload are released in the same time period by elevating the pH of the release medium or applying an alternating electric field. The two stimuli signals can work independently or corporately to regulate the release kinetics to form a dual-mode drug delivery mechanism, which makes it more flexible for use in certain complicated situations.

Graphical abstract: Macromolecules on nano-outlets responding to electric field and pH for dual-mode drug delivery

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Publication details

The article was received on 05 Nov 2012, accepted on 16 Jan 2013 and first published on 18 Jan 2013


Article type: Paper
DOI: 10.1039/C3TB00362K
Citation: J. Mater. Chem. B, 2013,1, 1579-1583
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    Macromolecules on nano-outlets responding to electric field and pH for dual-mode drug delivery

    F. Li, Y. Zhu, Z. Mao, Y. Wang, Q. Ruan, J. Shi and C. Ning, J. Mater. Chem. B, 2013, 1, 1579
    DOI: 10.1039/C3TB00362K

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