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Issue 20, 2013
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Synthesis and cellular compatibility of multi-block biodegradable poly(ε-caprolactone)-based polyurethanes

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Abstract

A library of block copolymers was synthesized by varying the molecular weight of the poly(ε-caprolactone) (PCL)-diol soft segment (Mw = 850, 3050, 3700 or 7000), which was reacted with methylene diphenyl diisocyanate (MDI), 1,4-phenylene diisocyanate (PDI), 1,1′-methylenebis(4-isocyanatocyclohexane) (HMDI), or 2,4-toluene diisocyanate (TDI) with 1,4-butanediol (BD) or ethylene glycol (EG) added as chain extenders. Thermal and X-ray measurements indicated that the crystalline structure of the copolymers was largely dependent on the chain length of the PCL-diol, with no crystallization taking place with the smallest diol (Mw = 850) using MDI, TDI or HMDI. However, the copolymers produced from a PCL-diol (Mw = 850) and PDI and chain extenders (BD or EG) showed resolved crystalline peaks while no peaks appeared with other diisocyanates. Hydrolytic degradation studies demonstrated a faster degradation rate in the case of more amorphous copolymers than semi-crystalline copolymers. The cellular compatibility of the copolymers was evaluated by fabricating the entire library of polymers in a microarray format and in vitro cell culture, demonstrating that all the 57 copolymers supported cellular attachment and growth.

Graphical abstract: Synthesis and cellular compatibility of multi-block biodegradable poly(ε-caprolactone)-based polyurethanes

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Publication details

The article was received on 04 Nov 2012, accepted on 19 Mar 2013 and first published on 19 Mar 2013


Article type: Paper
DOI: 10.1039/C3TB00358B
Citation: J. Mater. Chem. B, 2013,1, 2590-2600
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    Synthesis and cellular compatibility of multi-block biodegradable poly(ε-caprolactone)-based polyurethanes

    F. Khan, S. Valere, S. Fuhrmann, V. Arrighi and M. Bradley, J. Mater. Chem. B, 2013, 1, 2590
    DOI: 10.1039/C3TB00358B

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