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Issue 15, 2013
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Design of simultaneous antimicrobial and anticoagulant surfaces based on nanoparticles and polysaccharides

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Abstract

The rational design of silver nanoparticles encapsulated in an anticoagulant, hemocompatible polysaccharide, 6-O-chitosan sulfate, is presented. Three different approaches are described for the immobilization of these core shell particles on cellulosic surfaces. The mass of the immobilized particles is quantified using a quartz crystal microbalance with dissipation (QCM-D). The antimicrobial activity of the surfaces towards E. coli MG 1655 [R1-16] is investigated by live/dead assays using fluorescence staining. All surfaces treated with the designed nanoparticles exhibit excellent antimicrobial activity towards E. coli MG 1655 [R1-16]. Anticoagulant properties of blood plasma on the nanoparticle treated surfaces have been determined using QCM-D. In comparison with the unmodified substrates, the total coagulation time as well as the thrombin formation time and fibrin clotting time of surfaces modified with nanoparticles are significantly increased.

Graphical abstract: Design of simultaneous antimicrobial and anticoagulant surfaces based on nanoparticles and polysaccharides

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The article was received on 18 Oct 2012, accepted on 12 Feb 2013 and first published on 12 Feb 2013


Article type: Paper
DOI: 10.1039/C3TB00272A
Citation: J. Mater. Chem. B, 2013,1, 2022-2030
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    Design of simultaneous antimicrobial and anticoagulant surfaces based on nanoparticles and polysaccharides

    D. Breitwieser, S. Spirk, H. Fasl, H. M. A. Ehmann, A. Chemelli, V. E. Reichel, C. Gspan, K. Stana-Kleinschek and V. Ribitsch, J. Mater. Chem. B, 2013, 1, 2022
    DOI: 10.1039/C3TB00272A

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