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Issue 16, 2013
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Influenza A virus molecularly imprinted polymers and their application in virus sub-type classification

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Abstract

In this work, we apply a molecular imprinting strategy as a screening protocol for different influenza A subtypes, namely H5N1, H5N3, H1N1, H1N3 and H6N1. Molecularly imprinted polymers for each of these subtypes lead to appreciable sensor characteristics on a quartz crystal microbalance leading to detection limits as low as 105 particles per ml. Selectivity studies indicate that each virus is preferably incorporated by its own MIP. Recognition in most cases is dominated by the neuraminidase residue rather than the hemagglutinin. Multivariate analysis shows that the sensor responses can be correlated with the differences in hemagglutinin and neuraminidase patterns from databases. This allows for virus subtype characterization and thus rapid screening.

Graphical abstract: Influenza A virus molecularly imprinted polymers and their application in virus sub-type classification

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Publication details

The article was received on 08 Jan 2013, accepted on 18 Feb 2013 and first published on 19 Feb 2013


Article type: Paper
DOI: 10.1039/C3TB00027C
Citation: J. Mater. Chem. B, 2013,1, 2190-2197
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    Influenza A virus molecularly imprinted polymers and their application in virus sub-type classification

    T. Wangchareansak, A. Thitithanyanont, D. Chuakheaw, M. P. Gleeson, P. A. Lieberzeit and C. Sangma, J. Mater. Chem. B, 2013, 1, 2190
    DOI: 10.1039/C3TB00027C

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