Codendrimer (PAG) from polyamidoamine (PAMAM) and oligoethylene glycols (OEG) dendron: evaluation as drug carrier

Abstract

Based on the successful synthesis of codendrimer PAMAM-co-OEG (PAG) from polyamidoamine (PAMAM) and oligoethylene glycols (OEG) dendron, the aim of this paper was to prepare drug-loaded aggregates and evaluate the ability of PAG as the drug carrier. A series of hydrophobic drugs with different functional groups were selected as model drugs. The drug-loading procedures were optimized by single factor exploration with resveratrol. From the results of drug-loading content (DLC) and entrapment efficiency (EE), MTX was proved to be the most suitable drug. Moreover, higher loading capacity and slower in vitro release of MTX were observed, which was due to the hydrophobic interactions and electrostatic interactions between MTX and PAG. In summary, PAG exhibited great potential for modifications in the stability, drug solubilization, and release properties of drug-loaded aggregates.