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Issue 4, 2013
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A novel fluorescent probe for selective detection of thiols in acidic solutions and labeling of acidic organelles in live cells

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Abstract

A novel fluorescent probe, quinoline α,β-unsaturated diacid (QMA), as compared to its ester QME, was constructed and can selectively detect thiols in acidic solutions (pH < 7) via a H-bond activated Michael addition. Furthermore, labeling of lysosomes and cell imaging were achieved by the detection of biothiols in different domains of live cells.

Graphical abstract: A novel fluorescent probe for selective detection of thiols in acidic solutions and labeling of acidic organelles in live cells

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Publication details

The article was received on 12 Nov 2012, accepted on 04 Dec 2012 and first published on 05 Dec 2012


Article type: Communication
DOI: 10.1039/C2TB00402J
Citation: J. Mater. Chem. B, 2013,1, 438-442
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    A novel fluorescent probe for selective detection of thiols in acidic solutions and labeling of acidic organelles in live cells

    Q. Song, Q. Wu, C. Liu, X. Du and Q. Guo, J. Mater. Chem. B, 2013, 1, 438
    DOI: 10.1039/C2TB00402J

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