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Issue 2, 2013
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Microspheres as therapeutic delivery agents: synthesis and biological evaluation of pH responsiveness

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Abstract

A soft template method was used for the synthesis of pH-responsive microcontainers with an inner cavity. Poly(glycidyl methacrylate) (PGMA) microspheres of narrow size distribution were synthesized by soap-free radical emulsion polymerization and the coating of the microspheres was carried out by the same procedure. The procedure consists of two steps. In the first step the sacrificial template is synthesized and in the second step the shell is formed. Acrylic acid was used as a coating monomer, with the aim of introducing pH sensitivity in the synthesized microcontainers. A loading and release study of the anthracycline drug doxorubicin (DOX) was also carried out. The toxicity evaluation of the drug was carried out using the MTT assay, and the necrotic effect was studied using trypan blue.

Graphical abstract: Microspheres as therapeutic delivery agents: synthesis and biological evaluation of pH responsiveness

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Publication details

The article was received on 23 Aug 2012, accepted on 01 Oct 2012 and first published on 02 Oct 2012


Article type: Paper
DOI: 10.1039/C2TB00013J
Citation: J. Mater. Chem. B, 2013,1, 194-203
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    Microspheres as therapeutic delivery agents: synthesis and biological evaluation of pH responsiveness

    C. Tapeinos, E. K. Efthimiadou, N. Boukos, C. A. Charitidis, M. Koklioti and G. Kordas, J. Mater. Chem. B, 2013, 1, 194
    DOI: 10.1039/C2TB00013J

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