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Issue 25, 2013
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Submicron hybrid vesicles consisting of polymerlipid and polymercholesterol blends

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Abstract

Hybrid polymerlipid and polymercholesterol submicron unilamellar vesicles with a diameter of ∼200 nm based on poly(dimethylsiloxane)-block-poly(2-methyl-oxazoline) (PDMS-b-PMOXA) and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) were prepared by using the film-hydration and extrusion method. The vesicles were extensively characterized via dynamic and static light scattering (DLS and SLS), dual-color fluorescence cross-correlation spectroscopy (DC-FCCS), cryogenic transmission electron microscopy (cryo-TEM) and atomic force microscopy imaging and force spectroscopy (AFM). The combination of these techniques provides information about the vesicle size, shape and long-term stability as well as the mechanical properties. DC-FCCS proved the formation of hybrid vesicles containing both components. Cryo-TEM and AFM studies revealed that the presence of cholesterol in vesicle membranes leads to a higher packing density resulting in a reduced membrane thickness and a significantly increased bending stiffness compared to pure polymersomes and polymerlipid vesicles.

Graphical abstract: Submicron hybrid vesicles consisting of polymer–lipid and polymer–cholesterol blends

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Publication details

The article was received on 14 Mar 2013, accepted on 21 Apr 2013 and first published on 15 May 2013


Article type: Paper
DOI: 10.1039/C3SM50733E
Citation: Soft Matter, 2013,9, 5883-5890
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    Submicron hybrid vesicles consisting of polymerlipid and polymercholesterol blends

    S. Winzen, M. Bernhardt, D. Schaeffel, A. Koch, M. Kappl, K. Koynov, K. Landfester and A. Kroeger, Soft Matter, 2013, 9, 5883
    DOI: 10.1039/C3SM50733E

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