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Issue 27, 2013
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How the chain configuration governs the packing of inverted micelles in the cubic Fd3m-phase

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Abstract

The inverted micellar cubic Fd3m phase has attracted significant interest in drug delivery and is also of special biological relevance in the early steps of fat digestion. Applying small angle X-ray diffraction (SAXD) the stability of the Fd3m phase with respect to the chain configuration has been examined. In particular, the fully hydrated monoelaidin system containing the trans elaidic or its counterpart cis oleic fatty acid was investigated. Re-analyzed data of a fully hydrated monoolein–oleic acid (MO–OA) mixture complete this study (data taken from Luzzati et al.). On the basis of determined electron density maps, minute structural details are presented. The decomposition of the cubic Fd3m nanostructure into its apolar and polar moieties allowed the estimation of chain length and water radius depending on the fatty acid content. An increase in the elaidic chain concentration increases the membrane monolayer thickness, and in particular reduces the sphericity of the polar envelope of the small micelles. Furthermore, the electron density maps revealed the geometry of the space filling 512 and 51264 cages of the Fd3m phase as well as the loci of the greatest packing stress, which are situated at vertices of the 51264 cages that are placed opposite the hexagonal faces.

Graphical abstract: How the chain configuration governs the packing of inverted micelles in the cubic Fd3m-phase

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Publication details

The article was received on 29 Jan 2013, accepted on 01 May 2013 and first published on 05 Jun 2013


Article type: Paper
DOI: 10.1039/C3SM50308A
Citation: Soft Matter, 2013,9, 6291-6300
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    How the chain configuration governs the packing of inverted micelles in the cubic Fd3m-phase

    M. Rappolt, F. Cacho-Nerin, C. Morello and A. Yaghmur, Soft Matter, 2013, 9, 6291
    DOI: 10.1039/C3SM50308A

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