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Issue 13, 2013
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Self-assembly of a peptide amphiphile: transition from nanotape fibrils to micelles

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Abstract

A thermal transition is observed in the peptide amphiphile C16-KTTKS (TFA salt) from nanotapes at 20 °C to micelles at higher temperature (the transition temperature depending on concentration). The formation of extended nanotapes by the acetate salt of this peptide amphiphile, which incorporates a pentapeptide from type I procollagen, has been studied previously [V. Castelletto et al., Chem. Commun., 2010, 46, 9185]. Here, proton NMR and SAXS provide evidence for the TFA salt spherical micelles at high temperature. The phase behavior, with a Krafft temperature separating insoluble aggregates (extended nanotapes) at low temperature from the high temperature micellar phase resembles that for conventional surfactants, however this has not previously been reported for peptide amphiphiles.

Graphical abstract: Self-assembly of a peptide amphiphile: transition from nanotape fibrils to micelles

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Publication details

The article was received on 19 Dec 2012, accepted on 08 Feb 2013 and first published on 20 Feb 2013


Article type: Paper
DOI: 10.1039/C3SM27899A
Citation: Soft Matter, 2013,9, 3558-3564
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    Self-assembly of a peptide amphiphile: transition from nanotape fibrils to micelles

    J. F. Miravet, B. Escuder, M. D. Segarra-Maset, M. Tena-Solsona, I. W. Hamley, A. Dehsorkhi and V. Castelletto, Soft Matter, 2013, 9, 3558
    DOI: 10.1039/C3SM27899A

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