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Issue 15, 2013
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Poly(vinylamine) microgels: pH-responsive particles with high primary amine contents

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Abstract

pH-responsive microgels are crosslinked polymer colloid particles that swell when the pH approaches the pKa of the polybase or polyacid chains. Poly(vinylamine) (PVAM) has the highest primary amine content of all amine-containing polymers. Despite much effort the preparation of colloidally stable PVAM microgels is still elusive. Here, we introduce a simple and scalable, two-step method for preparation of pH-responsive PVAM microgels. First, non-aqueous dispersion (NAD) polymerization was used to prepare new monodisperse water-swellable poly(N-vinylformamide-co-2-(N-vinylformamido)ethyl ether microgels (PNVF-xNVEE). Here, x is the mol% of the alkali-stable crosslinker (NVEE) used. Alkali-hydrolysis of the PNVF-xNVEE microgels in water gave colloidally stable poly(vinylamine-co-bis(ethyl vinylamine)ether) (PVAM-xBEVAME) microgel dispersions. SEM images showed that both the PNVF-9NVEE and PVAM-9BEVAME microgel particles had cluster-like morphologies. The PVAM-xBEVAME particles were positively charged at pH values less than 12. The hydrodynamic diameters and electrophoretic mobilities increased strongly as the pH decreased. In order to demonstrate that primary amines could be used as chemical handles for conjugation, pyrene carboxylic acid was coupled using N-(3-dimethylaminopropyl)-Nā€²-ethylcarbodiimide (EDC) chemistry and its presence confirmed by fluorescence microscopy. Because this new family of colloidally stable microgels has very high primary amine contents and was prepared by a scalable synthetic method there should be potential applications in a wide range of areas from surface coatings and new hybrid particles to delivery.

Graphical abstract: Poly(vinylamine) microgels: pH-responsive particles with high primary amine contents

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Publication details

The article was received on 27 Nov 2012, accepted on 07 Jan 2013 and first published on 16 Jan 2013


Article type: Paper
DOI: 10.1039/C3SM27728C
Citation: Soft Matter, 2013,9, 3920-3930
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    Poly(vinylamine) microgels: pH-responsive particles with high primary amine contents

    S. Thaiboonrod, C. Berkland, A. H. Milani, R. Ulijn and B. R. Saunders, Soft Matter, 2013, 9, 3920
    DOI: 10.1039/C3SM27728C

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