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Issue 8, 2013
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The emerging role of hydrogen bond interactions in polyglutamine structure, stability and association

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Abstract

Polyglutamine regions in proteins have been associated with protein aggregation and the development of serious neurodegenerative diseases. Using a bottom-up approach, the molecular properties of glutamine and single polyglutamine chains can be understood, providing a promising route to uncover the mechanisms of polyglutamine-related protein aggregation. In this article we highlight recent advances in the study of both glutamine and polyglutamine using novel biophysical tools. A recurring theme in these studies is the importance of hydrogen bonding in driving glutamine association.

Graphical abstract: The emerging role of hydrogen bond interactions in polyglutamine structure, stability and association

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Publication details

The article was received on 07 Nov 2012, accepted on 06 Dec 2012 and first published on 21 Dec 2012


Article type: Highlight
DOI: 10.1039/C2SM27565A
Citation: Soft Matter, 2013,9, 2359-2364
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    The emerging role of hydrogen bond interactions in polyglutamine structure, stability and association

    N. H. Rhys and L. Dougan, Soft Matter, 2013, 9, 2359
    DOI: 10.1039/C2SM27565A

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