Jump to main content
Jump to site search

Issue 1, 2013
Previous Article Next Article

pH-triggered self-assembly of biocompatible histamine-functionalized triblock copolymers

Author affiliations

Abstract

Histamine functionalized poly(allyl glycidyl ether)-b-poly(ethylene glycol)-b-poly(allyl glycidyl ether) (PAGE-PEO-PAGE) triblock copolymers represent a new class of physically cross-linked, pH-responsive hydrogels with significant potential for biomedical applications. These telechelic triblock copolymers exhibited abrupt and reversible hydrogelation above pH 7.0 due to a hydrophilic/hydrophobic transition of the histamine units to form a network of hydrophobic domains bridged by a hydrophilic PEO matrix. These hydrophobic domains displayed improved ordering upon increasing pH and self-assembled into a body centered cubic lattice at pH 8.0, while at lower concentrations formed well-defined micelles. Significantly, all materials were found to be non-toxic when evaluated on three different cell lines and suggests a range of medical and biomedical applications.

Graphical abstract: pH-triggered self-assembly of biocompatible histamine-functionalized triblock copolymers

Back to tab navigation

Supplementary files

Publication details

The article was received on 29 Aug 2012, accepted on 03 Oct 2012 and first published on 15 Oct 2012


Article type: Paper
DOI: 10.1039/C2SM26996A
Citation: Soft Matter, 2013,9, 82-89
  •   Request permissions

    pH-triggered self-assembly of biocompatible histamine-functionalized triblock copolymers

    P. Lundberg, N. A. Lynd, Y. Zhang, X. Zeng, D. V. Krogstad, T. Paffen, M. Malkoch, A. M. Nyström and C. J. Hawker, Soft Matter, 2013, 9, 82
    DOI: 10.1039/C2SM26996A

Search articles by author

Spotlight

Advertisements