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Issue 8, 2013
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Peptide-based targeting of fluorescent zinc sensors to the plasma membrane of live cells

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Abstract

Combining fluorescent zinc sensors with the facile syntheses and biological targeting capabilities of peptides, we created green- and blue-emitting probes that (i) are readily prepared on the solid-phase, (ii) retain the photophysical and zinc-binding properties of the parent sensor, and (iii) can be directed to the extracellular side of plasma membranes in live cells for detection of mobile zinc.

Graphical abstract: Peptide-based targeting of fluorescent zinc sensors to the plasma membrane of live cells

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The article was received on 11 Apr 2013, accepted on 14 May 2013 and first published on 29 May 2013


Article type: Edge Article
DOI: 10.1039/C3SC50974E
Citation: Chem. Sci., 2013,4, 3080-3084
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    Peptide-based targeting of fluorescent zinc sensors to the plasma membrane of live cells

    R. J. Radford, W. Chyan and S. J. Lippard, Chem. Sci., 2013, 4, 3080
    DOI: 10.1039/C3SC50974E

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