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Issue 6, 2013
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Rh(III)-catalyzed ortho-oxidative alkylation of unactivated arenes with allylic alcohols

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Abstract

Versatile directed aromatic C–H bond activation and oxidative coupling with allylic alcohols is reported using a cationic Rh(III) catalyst. This method provides efficient and robust synthesis of functional β-aryl ketones and indolines in good yields with excellent regioselectivity, even the reaction runs at 3 g scale. The catalytic systems have good functional group tolerance, such as CONR2, NHAc, NO2, CF3, CN, Cl, Br and I.

Graphical abstract: Rh(iii)-catalyzed ortho-oxidative alkylation of unactivated arenes with allylic alcohols

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Publication details

The article was received on 07 Mar 2013, accepted on 04 Apr 2013 and first published on 05 Apr 2013


Article type: Edge Article
DOI: 10.1039/C3SC50630D
Citation: Chem. Sci., 2013,4, 2665-2669
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    Rh(III)-catalyzed ortho-oxidative alkylation of unactivated arenes with allylic alcohols

    L. Huang, Q. Wang, J. Qi, X. Wu, K. Huang and H. Jiang, Chem. Sci., 2013, 4, 2665
    DOI: 10.1039/C3SC50630D

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