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Issue 6, 2013
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Chiral organic contact ion pairs in metal-free catalytic enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to ketones

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Abstract

A novel chiral organic contact ion-pair catalytic system has been developed for the transition-metal-free catalytic enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to ketones for sp3 C–H functionalization. This new strategy provides an efficient and environmentally friendly way to access diversify optically active C1-alkylated tetrahydroisoquinoline derivatives from simple starting materials under mild conditions.

Graphical abstract: Chiral organic contact ion pairs in metal-free catalytic enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to ketones

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Publication details

The article was received on 04 Mar 2013, accepted on 19 Mar 2013 and first published on 20 Mar 2013


Article type: Edge Article
DOI: 10.1039/C3SC50604E
Citation: Chem. Sci., 2013,4, 2645-2651
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    Chiral organic contact ion pairs in metal-free catalytic enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to ketones

    G. Zhang, Y. Ma, S. Wang, W. Kong and R. Wang, Chem. Sci., 2013, 4, 2645
    DOI: 10.1039/C3SC50604E

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