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Issue 4, 2013
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Enzyme inhibition by metal complexes: concepts, strategies and applications

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Abstract

Metal complexes are increasingly being used to inhibit enzymes. The reasons for this increased interest arise from the special features that metal complexes offer, e.g. the facile construction of 3D architectures that tightly fill enzyme active sites increasing selectivity and the possibility of facile coordination to protein residues that enhances enzyme inhibition. In this review we classify the main modes of enzyme inhibition by metal-based complexes and correlate the enzyme inhibition activity to macroscopic properties such as anticancer activity.

Graphical abstract: Enzyme inhibition by metal complexes: concepts, strategies and applications

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Publication details

The article was received on 31 Dec 2012, accepted on 12 Feb 2013 and first published on 18 Feb 2013


Article type: Minireview
DOI: 10.1039/C3SC22349C
Citation: Chem. Sci., 2013,4, 1410-1419
  • Open access: Creative Commons BY license
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    Enzyme inhibition by metal complexes: concepts, strategies and applications

    K. J. Kilpin and P. J. Dyson, Chem. Sci., 2013, 4, 1410
    DOI: 10.1039/C3SC22349C

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