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Edge Article

Spacer length shapes drug release and therapeutic efficacy of traceless disulfide-linked ADCs targeting the tumor neovasculature

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a
Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Wolfgang-Pauli Str. 10, 8093 Zürich, Switzerland
E-mail: Goncalo.Bernardes@pharma.ethz.ch, Goncalo.Bernardes@linacre.oxon.org;
Fax: +41 44633 1358
b
Philochem AG, Libernstrasse 3, 8112 Otelfingen, Switzerland
c
Department of Biochemistry, University of Zürich, Winterthurerstr. 190, 8057 Zürich, Switzerland
d
Department of Biology, Institute of Molecular Biology and Biophysics, Swiss Federal Institute of Technology (ETH Zürich), Schafmattstrasse 20, 8093 Zürich, Switzerland
Chem. Sci., 2013,4, 297-302

DOI: 10.1039/C2SC21107F
Received 28 Jul 2012, Accepted 05 Oct 2012
First published online 08 Oct 2012
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