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Issue 10, 2013
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Helical poly(arginine) mimics with superior cell-penetrating and molecular transporting properties

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Abstract

Poly(arginine) mimics bearing long hydrophobic side chains adopt a stable helical conformation and exhibit helix-related cell-penetrating properties. Elongating the polypeptide backbone length and increasing side chain hydrophobicity further increase the helicities of poly(arginine) mimics. These helical poly(arginine) mimics show superior cell membrane permeability up to two orders of magnitude higher than that of HIV-TAT peptide and excellent DNA and siRNA delivery efficiencies in various mammalian cells.

Graphical abstract: Helical poly(arginine) mimics with superior cell-penetrating and molecular transporting properties

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Publication details

The article was received on 13 May 2013, accepted on 12 Jul 2013 and first published on 09 Aug 2013


Article type: Edge Article
DOI: 10.1039/C3SC51328A
Citation: Chem. Sci., 2013,4, 3839-3844
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    Helical poly(arginine) mimics with superior cell-penetrating and molecular transporting properties

    H. Tang, L. Yin, K. H. Kim and J. Cheng, Chem. Sci., 2013, 4, 3839
    DOI: 10.1039/C3SC51328A

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