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Issue 2, 2013
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Catalytic asymmetric synthesis of highly substituted pyrrolizidines

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Abstract

A catalytic asymmetric double (1,3)-dipolar cycloaddition reaction has been developed. Using a chiral silver catalyst, enantioenriched pyrrolizidines can be prepared in one flask from inexpensive, commercially available starting materials. The pyrrolizidine products contain a variety of substitution patterns and as many as six stereogenic centers.

Graphical abstract: Catalytic asymmetric synthesis of highly substituted pyrrolizidines

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Publication details

The article was received on 28 Sep 2012, accepted on 31 Oct 2012 and first published on 13 Nov 2012


Article type: Edge Article
DOI: 10.1039/C2SC21617E
Citation: Chem. Sci., 2013,4, 650-654
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    Catalytic asymmetric synthesis of highly substituted pyrrolizidines

    A. D. Lim, J. A. Codelli and S. E. Reisman, Chem. Sci., 2013, 4, 650
    DOI: 10.1039/C2SC21617E

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