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Issue 40, 2013
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Photobactericidal polymers; the incorporation of crystal violet and nanogold into medical grade silicone

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Abstract

Crystal violet and 2 nm gold nanoparticles were incorporated into medical grade silicone polymers by use of a novel two-step dipping strategy using water and wateracetone mixtures. Optical microscopic examination showed that the optimised polymer incorporated dye close to the polymer surface, with minimal dye encapsulation throughout the polymer bulk. The modified polymer was stable under aqueous conditions with negligible leaching of crystal violet from the polymer into surrounding aqueous solution at 37 °C. Exposure of the modified silicone to low power 635 nm laser light induced the lethal photosensitisation of both Staphylococcus epidermidis and Escherichia coli. Despite the laser used not matching the absorption maximum of the crystal violet-containing silicone samples, the lethal photosensitisation was the highest reported, in terms of bacterial kill per energy dose. Furthermore, surprisingly, some statistically significant dark kill was also noted.

Graphical abstract: Photobactericidal polymers; the incorporation of crystal violet and nanogold into medical grade silicone

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Publication details

The article was received on 12 Mar 2013, accepted on 25 Jun 2013 and first published on 08 Jul 2013


Article type: Paper
DOI: 10.1039/C3RA42629G
Citation: RSC Adv., 2013,3, 18383-18394
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    Photobactericidal polymers; the incorporation of crystal violet and nanogold into medical grade silicone

    S. Noimark, M. Bovis, A. J. MacRobert, A. Correia, E. Allan, M. Wilson and I. P. Parkin, RSC Adv., 2013, 3, 18383
    DOI: 10.1039/C3RA42629G

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