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Issue 24, 2013
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A recyclable CuO-catalyzed synthesis of 4(3H)-quinazolinones

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Abstract

This paper describes the synthesis of 2-substituted and 2,3-disubstituted 4(3H)-quinazolinones via a tandem reaction involving anthranilamides and aromatic aldehydes catalyzed by 3 mol% CuO powder under air atmosphere. This new method has several advantages: it uses recyclable and cheap CuO powder as the catalyst and air as the green oxidant, water is the only byproduct, and the solvent is recycled. It is easy to run, has a high atom economy and good to excellent yields. A mechanism for the CuO-catalyzed synthesis of the 4(3H)-quinazolinones is proposed.

Graphical abstract: A recyclable CuO-catalyzed synthesis of 4(3H)-quinazolinones

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Publication details

The article was received on 13 Dec 2012, accepted on 28 Mar 2013 and first published on 03 Apr 2013


Article type: Paper
DOI: 10.1039/C3RA41370E
Citation: RSC Adv., 2013,3, 9325-9329
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    A recyclable CuO-catalyzed synthesis of 4(3H)-quinazolinones

    D. Zhan, T. Li, H. Wei, W. Weng, K. Ghandi and Q. Zeng, RSC Adv., 2013, 3, 9325
    DOI: 10.1039/C3RA41370E

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