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Issue 26, 2013
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Highly efficient and environmentally benign preparation of Weinreb amides in the biphasic system 2-MeTHF/water

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Abstract

A straightforward chromatography-free preparation of Weinreb amides starting from acid halides has been achieved in the biphasic medium 2-MeTHF/water. Analytically pure compounds were isolated in excellent yields simply after removal of 2-MeTHF, which absolutely avoids the use of any contaminant organic solvent within the whole process due to its (practically) immiscibility with water.

Graphical abstract: Highly efficient and environmentally benign preparation of Weinreb amides in the biphasic system 2-MeTHF/water

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Publication details

The article was received on 03 Feb 2013, accepted on 12 Apr 2013 and first published on 15 Apr 2013


Article type: Communication
DOI: 10.1039/C3RA41262H
Citation: RSC Adv., 2013,3, 10158-10162
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    Highly efficient and environmentally benign preparation of Weinreb amides in the biphasic system 2-MeTHF/water

    V. Pace, L. Castoldi, A. R. Alcántara and W. Holzer, RSC Adv., 2013, 3, 10158
    DOI: 10.1039/C3RA41262H

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