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Issue 27, 2013
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Iodine-catalyzed oxidative system for cyclization of primary alcohols with o-aminobenzamides to quinazolinones using DMSO as the oxidant in dimethyl carbonate

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Abstract

The iodine catalyzed one-pot two-step oxidative system for cyclization of primary alcohols with o-aminobenzamides to quinazolinones using DMSO as the oxidant has been achieved, providing a convenient and efficient method for the synthesis of quinazolinones in good to excellent yields via in situ oxidation of primary alcohols to aldehydes. The reaction was carried out in the green solvent DMC, under atmospheric conditions. The procedure is suitable for aromatic or alkyl primary alcohols.

Graphical abstract: Iodine-catalyzed oxidative system for cyclization of primary alcohols with o-aminobenzamides to quinazolinones using DMSO as the oxidant in dimethyl carbonate

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Publication details

The article was received on 20 Feb 2013, accepted on 19 Apr 2013 and first published on 19 Apr 2013


Article type: Paper
DOI: 10.1039/C3RA40872H
Citation: RSC Adv., 2013,3, 10817-10822
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    Iodine-catalyzed oxidative system for cyclization of primary alcohols with o-aminobenzamides to quinazolinones using DMSO as the oxidant in dimethyl carbonate

    W. Ge, X. Zhu and Y. Wei, RSC Adv., 2013, 3, 10817
    DOI: 10.1039/C3RA40872H

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